Photo by Visit Greenville, South Carolina
Find hotels in Upstate South Carolina, SC from $66
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Go beyond your typical stay in Upstate South Carolina
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Our top choices for Upstate South Carolina hotels
Deluxe Inn
Deluxe InnMauldin
10.0 out of 10, Exceptional, (2 reviews)
$61 nightly
The price is $68
May 29 - May 30
Total with taxes and fees
Carolina Inn Anderson Clemson Area
Carolina Inn Anderson Clemson AreaAnderson
10.0 out of 10, Exceptional, (1 review)
"The staff is great "
Luis Fernando
$55 nightly
The price is $61
May 17 - May 18
Total with taxes and fees
Carolina Camp Cedar
Carolina Camp CedarPickens
10.0 out of 10, Exceptional, (3 reviews)
"The cottage was clean, staff was so friendly, our stay was quiet and peaceful… it was perfect! Definitely planning to stay there again!"
Katlynn
$231 nightly
The price is $256
May 17 - May 18
Total with taxes and fees
Quality Inn Seneca Clemson Area US-123
Quality Inn Seneca Clemson Area US-123Downtown
8.0 out of 10, Very Good, (702 reviews)
"Clean room comfortable beds"
Cheryl
$91 nightly
The price is $99
Jun 14 - Jun 15
Total with taxes and fees
Hampton Inn Greer Greenville, SC
Hampton Inn Greer Greenville, SCGreer
9.6 out of 10, Exceptional, (458 reviews)
"great service all around."
Alberto
$139 nightly
The price is $152
May 17 - May 18
Total with taxes and fees
Hampton Inn Easley
Hampton Inn EasleyEasley
9.2 out of 10, Wonderful, (710 reviews)
"Great staff, left a lasting impression. "
Jenine
$122 nightly
The price is $136
Jun 7 - Jun 8
Total with taxes and fees
Lakeside Lodge Clemson
Lakeside Lodge ClemsonSeneca
9.0 out of 10, Wonderful, (1,003 reviews)
"This place is tops! The area is great, rooms were wonderful, and amenities were amazing. Definitely plan on staying again asap!"
Valarie Tina
$123 nightly
The price is $135
May 17 - May 18
Total with taxes and fees
Fairfield Inn & Suites Seneca Clemson Univ Area
Fairfield Inn & Suites Seneca Clemson Univ AreaSeneca
9.4 out of 10, Exceptional, (230 reviews)
"Excellent in every way … staff, room, amenities and very comfortable bed!"
Sarah
$129 nightly
The price is $142
May 24 - May 25
Total with taxes and fees
Clemson University's James F. Martin Inn
Clemson University's James F. Martin InnClemson
9.4 out of 10, Exceptional, (1,010 reviews)
"Lovely place to stay right on the lake. "
Sara
$149 nightly
The price is $165
May 17 - May 18
Total with taxes and fees
Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG
Holiday Inn Express Hotel & Suites Anderson-I-85 by IHGAnderson
9.2 out of 10, Wonderful, (615 reviews)
"Clean rooms, friendly staff, great breakfast options!"
Lauren
$110 nightly
The price is $122
May 24 - May 25
Total with taxes and fees
Hilton Garden Inn Anderson
Hilton Garden Inn AndersonAnderson
9.0 out of 10, Wonderful, (724 reviews)
"Great place to stay"
Maureen
$99 nightly
The price is $110
May 24 - May 25
Total with taxes and fees
The Inn at Patrick Square
The Inn at Patrick SquareClemson
9.8 out of 10, Exceptional, (846 reviews)
"We always wanted to stay here whenever we were visiting Clemson, and we finally did … and we’re not disappointed. Our stay was great!"
Roberto
$159 nightly
The price is $176
May 17 - May 18
Total with taxes and fees
Clemson Memorabilia House
Clemson Memorabilia HouseClemson
9.6 out of 10, Exceptional, (10 reviews)
"We enjoyed our stay, it was the perfect size for our family of four. "
Ashley
$214 nightly
The price is $238
May 19 - May 20
Total with taxes and fees
Comfort Inn & Suites Greer - Greenville
Comfort Inn & Suites Greer - GreenvilleGreer
8.6 out of 10, Excellent, (789 reviews)
"Wonderful stay - everything was perfect "
Paula
$105 nightly
The price is $114
May 24 - May 25
Total with taxes and fees
Embassy Suites Greenville Golf Resort & Conference Center
Embassy Suites Greenville Golf Resort & Conference CenterGreenville
9.0 out of 10, Wonderful, (1,202 reviews)
"The breakfast was amazing the room was clean it’s definitely worth the price"
Kylasha
$110 nightly
The price is $121
May 24 - May 25
Total with taxes and fees
Hampton Inn Gaffney
Hampton Inn GaffneyGaffney
8.8 out of 10, Excellent, (713 reviews)
"Would stay again breakfast was amazing "
Theresa
$83 nightly
The price is $91
May 31 - Jun 1
Total with taxes and fees
The Abernathy of Clemson
The Abernathy of ClemsonClemson
9.6 out of 10, Exceptional, (599 reviews)
"Easy parking, great location. Will stay there again"
William
$150 nightly
The price is $166
May 17 - May 18
Total with taxes and fees
Comfort Inn & Suites Clemson - University Area
Comfort Inn & Suites Clemson - University AreaClemson
8.4 out of 10, Very Good, (1,001 reviews)
"Great breakfast and friendly staff made our stay enjoyable."
Lon
$101 nightly
The price is $112
Jun 7 - Jun 8
Total with taxes and fees
Courtyard by Marriott Greenville Mauldin
Courtyard by Marriott Greenville MauldinGreenville
9.2 out of 10, Wonderful, (339 reviews)
"Hotel was very clean."
Bernard
$119 nightly
The price is $131
May 17 - May 18
Total with taxes and fees
Holiday Inn Express Gaffney by IHG
Holiday Inn Express Gaffney by IHGGaffney
8.8 out of 10, Excellent, (488 reviews)
"Room very clean staff was great breakfast was really good with lots of options "
melvin
$84 nightly
The price is $92
Jun 14 - Jun 15
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Vacation Rentals in Upstate South Carolina
Cabin
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott BonvoySeneca
9.8 out of 10, Exceptional, (73 reviews)
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Stay near popular Upstate South Carolina attractions
Learn more about Upstate South Carolina
Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.
Photo by Visit Greenville, South Carolina
Open Photo by Visit Greenville, South Carolina
Top Upstate South Carolina Hotel Reviews
Comfort Inn Greenville - Haywood Mall
6/10 Okay
More cheap stays in Upstate South Carolina
Sleep Inn Spartanburg Southwest
501 South Blackstock Rd Spartanburg SC
$59 nightly
The price is $66 total per night from Jun 14 to Jun 15
$66 total
Jun 14 - Jun 15
Total with taxes and fees
6/10 (601 reviews)
Hotels in Upstate South Carolina with star-rating
4 Star Hotels
38 properties
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